Configure at Admin Dashboard → Fresco Theme, then go to Layouts to set the grid widths and allocated positions.

There are Gizmos that are injected into a site when enabled in the Administrator, and are stacked vertically.

These are the Google Analytics, Page Suffix, Smart Load Images, Typography Shortcodes, Page Class Suffix, RokStyle, Build Title-Spans, Disable Auto Paragraphs, Disable Texturize and IE6 Redirect.

There are times when you just don't want to have your widgets taking up all the room in a horizontal row no matter what the layout. For example you might want to have a widget on the left and a widget on the right, with nothing in the middle.

This is made easy with Gantry with the Force Positions parameter for each layout, allowing you to set the count to a specific row number, such as 4, even if 4 widgets are not published for that row.